49ers did one thing Sunday night that made Peyton Manning really mad (GIF)

For most of the game against the 49ers Sunday night Peyton Manning had a big grin on his face. And why not? The Broncos quarterback had set an NFL record for career touchdown passes, toyed with the Niners defense and even got to spend the fourth quarter relaxing on the bench during his team's 42-17 blowout win.

Then the visitors called a useless timeout while they were trailing 42-10 with three minutes left in the game to preserve the clock, and Manning just shook his head.

But when San Francisco also took a timeout before an extra point attempt after scoring a touchdown with one minute left, Manning's dismay turned into a WTF.

Read his lips:

At least he can smile knowing he has the historic football to take home with him. Oops, about that spot on your mantle, Peyton.